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编 号：F306575
分子式：C19H21N5O2
分子量：351.4
分子式：C19H21N5O2
分子量：351.4
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CAS No: 28797-61-7
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生物活性：
Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells.
体内研究：
Pirenzepine (intraperitoneal injection; 0.3?mg/kg; once) treatment shows beneficial effects in lipopolysaccharide-induced septic shock.Animal Model:Male C57BL/6 mice with experimental endotoxemia
Dosage:0.3?mg/kg
Administration:Intraperitoneal injection; 0.3?mg/kg; once
Result:Improved survival rate of LPS-induced septic shock.Relieved LPS-induced pulmonary and hepatic injury.Reduced the expression of SOCS3 at mRNA level.
体外研究：
Pirenzepine (100-140 μg/mL; 24 h) inhibits PC-3 cell proliferation activity.Pirenzepine (110 μg/mL; 24 h) inhibits prostate and lung cancer cell migration.Pirenzepine (100-130 μg/mL; 0-24 h) inhibits the expression of GLI1 in PC-3 cells.
Pirenzepine (LS 519 free base) is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine shows anti-proliferative activity to cancer cells.
体内研究：
Pirenzepine (intraperitoneal injection; 0.3?mg/kg; once) treatment shows beneficial effects in lipopolysaccharide-induced septic shock.Animal Model:Male C57BL/6 mice with experimental endotoxemia
Dosage:0.3?mg/kg
Administration:Intraperitoneal injection; 0.3?mg/kg; once
Result:Improved survival rate of LPS-induced septic shock.Relieved LPS-induced pulmonary and hepatic injury.Reduced the expression of SOCS3 at mRNA level.
体外研究：
Pirenzepine (100-140 μg/mL; 24 h) inhibits PC-3 cell proliferation activity.Pirenzepine (110 μg/mL; 24 h) inhibits prostate and lung cancer cell migration.Pirenzepine (100-130 μg/mL; 0-24 h) inhibits the expression of GLI1 in PC-3 cells.
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