产品
编 号:F306207
分子式:C15H12N2O2
分子量:252.27
产品类型
结构图
CAS No: 28721-07-5
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产品详情
生物活性:
Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
体内研究:
Oxcarbazepine protectes mice and rats against generalized tonic-clonic seizures induced by electroshock with ED50 values between 13.5 and 20.5 mg/kg p.o. No tolerance toward this anticonvulsant effect is observed when rats are treated with Oxcarbazepine daily for 4 weeks.
体外研究:
Oxcarbazepine significantly inhibits glioblastoma cell growth and reaches IC50 at therapeutic concentrations. The IC50s of Oxcarbazepine screened with the U87 and T98 cell lines are 12.35 and 9.45 μg/mL,respectively.