产品
编 号：F305685
分子式：C21H20O11
分子量：448.38
分子式：C21H20O11
分子量：448.38
产品类型
规格
价格
是否有货
5mg
192
In-stock
10mg
304
In-stock
25mg
576
In-stock
结构图
CAS No: 28608-75-5
产品详情
生物活性：
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain.
体内研究：
Orientin (0.1–10 mg/kg，口服；1 次) 抑制了 PCA 小鼠模型的过敏反应。Orientin (10–40 mg/kg，腹腔注射；每日 1 次，连用 12 天) 在 SNL 大鼠模型中有抗神经炎症作用。Animal Model:PCA mouse model
Dosage:0.1–10 mg/kg
Administration:Oral gavage (p.o.); Euthanized mouse after 1 h
Result:Significantly suppressed PCA reactions in PCA mouse model.
Animal Model:SNL rat model
Dosage:10, 20, 40 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for 12 days
Result:Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model.Decreased the levels of IL-6, IL-1β and TNF-α.Increased the level of anti-inflammatory IL-10. Down-regulated the level of MDA.
体外研究：
Orientin (1 μM) 抑制了 RBL-2H3，mBMMC 和 RPMC 细胞的过敏性炎症。
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain.
体内研究：
Orientin (0.1–10 mg/kg，口服；1 次) 抑制了 PCA 小鼠模型的过敏反应。Orientin (10–40 mg/kg，腹腔注射；每日 1 次，连用 12 天) 在 SNL 大鼠模型中有抗神经炎症作用。Animal Model:PCA mouse model
Dosage:0.1–10 mg/kg
Administration:Oral gavage (p.o.); Euthanized mouse after 1 h
Result:Significantly suppressed PCA reactions in PCA mouse model.
Animal Model:SNL rat model
Dosage:10, 20, 40 mg/kg
Administration:Intraperitoneal injection (i.p.); Once daily for 12 days
Result:Alleviated the downreg-ulation of PWL and promoted the behavior recovery in SNL rat model.Decreased the levels of IL-6, IL-1β and TNF-α.Increased the level of anti-inflammatory IL-10. Down-regulated the level of MDA.
体外研究：
Orientin (1 μM) 抑制了 RBL-2H3，mBMMC 和 RPMC 细胞的过敏性炎症。
产品资料
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