产品
编 号：F036035
分子式：C20H37N3O4
分子量：383.53
分子式：C20H37N3O4
分子量：383.53
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 110044-82-1
产品详情
生物活性：
MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.
体内研究：
MG-101 (10 mg/kg；ip 每天一次，持续 15 天) 抑制裸鼠体内的肿瘤生长。Animal Model:Female athymic nude mice with HCT116 cells injection
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg once daily; for 15 days
Result:Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
体外研究：
MG-101 (0-26 μM；24 h) 影响结肠癌HCT116细胞的生长。 MG-101 (0-26 μM；24 h) 诱导细胞凋亡多种癌细胞。 MG-101 (0-26 μM；24 h) 诱导 HCT116 细胞发生 Bax 依赖性细胞凋亡。
MG-101 (ALLN) is an inhibitor of cysteine proteases which inhibits calpain I, calpain II, cathepsin B and cathepsin L with Kis of 190, 220, 150 and 500 pM, respectively. MG-101 induces apoptosis and inhibits tumor growth, it can be used for the research of colon cancer.
体内研究：
MG-101 (10 mg/kg；ip 每天一次，持续 15 天) 抑制裸鼠体内的肿瘤生长。Animal Model:Female athymic nude mice with HCT116 cells injection
Dosage:10 mg/kg
Administration:Intraperitoneal injection; 10 mg/kg once daily; for 15 days
Result:Significantly decreased tumor weight and volume of treated mice at day 26 compared to control mice, and showed no effect on body weights.
体外研究：
MG-101 (0-26 μM；24 h) 影响结肠癌HCT116细胞的生长。 MG-101 (0-26 μM；24 h) 诱导细胞凋亡多种癌细胞。 MG-101 (0-26 μM；24 h) 诱导 HCT116 细胞发生 Bax 依赖性细胞凋亡。
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