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编 号：F305490
分子式：C40H63N9O8S
分子量：830.05
分子式：C40H63N9O8S
分子量：830.05
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CAS No: 285571-64-4
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生物活性：
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research.
体内研究：
Barusiban (intravenous injection; 50 or 150 μg/kg; once) treatment shows inhibition on OT-induced contractions.Animal Model:Pregnant cynomolgus monkeys injected with oxytocin (OT)
Dosage:50 or 150 μg/kg
Administration:Intravenous injection; 50 or 150 μg/kg; once
Result:Reduced uterine contractions to baseline levels effectively.Reduced intrauterine pressure (IUP) from 6-7.5 kmm Hg?h to approximately 1 kmm Hg?h.
体外研究：
Barusiban shows affinity for oxytocin receptor (Ki=0.8 nM) in COS cells expressed with oxytocin receptor.
Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research.
体内研究：
Barusiban (intravenous injection; 50 or 150 μg/kg; once) treatment shows inhibition on OT-induced contractions.Animal Model:Pregnant cynomolgus monkeys injected with oxytocin (OT)
Dosage:50 or 150 μg/kg
Administration:Intravenous injection; 50 or 150 μg/kg; once
Result:Reduced uterine contractions to baseline levels effectively.Reduced intrauterine pressure (IUP) from 6-7.5 kmm Hg?h to approximately 1 kmm Hg?h.
体外研究：
Barusiban shows affinity for oxytocin receptor (Ki=0.8 nM) in COS cells expressed with oxytocin receptor.
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