产品
编 号：F304726
分子式：C22H19NO5
分子量：377.39
分子式：C22H19NO5
分子量：377.39
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
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询价
25mg
询价
询价
50mg
询价
询价
100mg
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结构图
CAS No: 28342-31-6
产品详情
生物活性：
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth.
体内研究：
Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice.Animal Model:Nude immunodeficient mice (5-week-old, weighing about 16 g)
Dosage:0.5 mg/kg
Administration:Subcutaneous injection; 5 times per week for 4 weeks
Result:Exhibited antitumor effects without reduce the body weight of the mice.
体外研究：
Ethoxysanguinarine inhibits cells vialibity with IC50 of 9.37 μM (SW480 cells); 7.19μM (HCT116 cells); 6.55 μM (HT69 cells); 3.57 μM (SW620 cells).Ethoxysanguinarine (3 μM or 5 μM, 24 h) down-regulates phospho-Akt, decreases CIP2A/PP2A/Akt pathway expression in the SW620 and HT29 cells.Ethoxysanguinarine (3 μM or 5 μM, 24 h) increases the PP2A activity and inhibits phosphorylation of CIP2A downstream molecule protein kinase B.Ethoxysanguinarine (1-3 μM or 4.5-5 μM, 24 h) decreases CIP2A transcription (protein level) and induces CIP2A proteolysis in the SW620 and HT29 cells.
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth.
体内研究：
Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice.Animal Model:Nude immunodeficient mice (5-week-old, weighing about 16 g)
Dosage:0.5 mg/kg
Administration:Subcutaneous injection; 5 times per week for 4 weeks
Result:Exhibited antitumor effects without reduce the body weight of the mice.
体外研究：
Ethoxysanguinarine inhibits cells vialibity with IC50 of 9.37 μM (SW480 cells); 7.19μM (HCT116 cells); 6.55 μM (HT69 cells); 3.57 μM (SW620 cells).Ethoxysanguinarine (3 μM or 5 μM, 24 h) down-regulates phospho-Akt, decreases CIP2A/PP2A/Akt pathway expression in the SW620 and HT29 cells.Ethoxysanguinarine (3 μM or 5 μM, 24 h) increases the PP2A activity and inhibits phosphorylation of CIP2A downstream molecule protein kinase B.Ethoxysanguinarine (1-3 μM or 4.5-5 μM, 24 h) decreases CIP2A transcription (protein level) and induces CIP2A proteolysis in the SW620 and HT29 cells.
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