产品
编 号：F303904
分子式：C18H19NO3
分子量：297.35
分子式：C18H19NO3
分子量：297.35
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2810-21-1
产品详情
生物活性：
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects.
体内研究：
Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex.Animal Model:Middle cerebral artery occlusion (MCAO) rat model.
Dosage:500 μg/kg (20 μL).
Administration:Intranasally injected into rats 1h after MCAO.
Result:Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.
体外研究：
Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells.Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation.Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro.
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects.
体内研究：
Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex.Animal Model:Middle cerebral artery occlusion (MCAO) rat model.
Dosage:500 μg/kg (20 μL).
Administration:Intranasally injected into rats 1h after MCAO.
Result:Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group.
体外研究：
Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells.Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation.Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro.
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