产品
编 号:F302538
分子式:C14H18N4O4
分子量:306.32
产品类型
结构图
CAS No: 27653-67-4
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产品详情
生物活性:
Trimethoprim 3-oxide (Trimethoprim 3-N-oxide) is the primary metabolite of trimethoprim.
体外研究:
Trimethoprim 3-oxide is the primary metabolite of trimethoprim.Trimethoprim 3-oxide (3-NO-TMP) is converted from trimethoprim by CYP1A1 and CYP1B1 with highest rates in human liver microsomes (HLMs). The CYP1A inhibitor α-Naphthoflavone inhibits Trimethoprim 3-oxide formation, however, other competitive P450 inhibitors has no obvious inhibition on the formation.