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编 号:F301417
分子式:C7H6N4O2
分子量:178.15
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10mM*1mL in DMSO
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50mg
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100mg
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200mg
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生物活性:
Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.

体内研究:
Tirapazamine (SR259075) (1mg; intravenously injected; twice at a 24-h interval) shows a synergetic effect to kill tumor cells because TPZ was activated under the hypoxic conditions that originated from the PDT with Pba and laser irradiation..Animal Model:C3H/HeN mice.
Dosage:1mg
Administration:Tirapazamine (1mg; intravenously injected; twice at a 24-h interval)
Result:Suppressed the tumors of mice by using laser irradiation.

体外研究:
Tirapazamine (SR259075) is the optimal drug for combination therapy using Pba.
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