产品
编 号：F299612
分子式：C16H16ClN3O3S
分子量：365.83
分子式：C16H16ClN3O3S
分子量：365.83
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价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
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1g
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5g
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结构图
CAS No: 26807-65-8
产品详情
生物活性：
Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy.
体内研究：
Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs).Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats.Animal Model:Male spontaneously hypertensive rats (11 weeks)
Dosage:1 mg/kg
Administration:Gastric gavage per day for 8 weeks
Result:Decreased blood pressure by 16.9 mm Hg.Increased the dp/dtmax, ejection fraction (EF) and fractional shortening (FS).
体外研究：
Indapamide (0.1-500 mg/L; 20min) reduces total insulin secretory response to glucose infusions in isolated perfused rat pancreas.Indapamide (1-100 μM) increases osteoblast proliferation and decreased bone resorption.
Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy.
体内研究：
Indapamide (1 mg/kg/d; gastric gavage for 8 weeks) lowers blood pressure in spontaneously hypertensive rats (SHRs).Indapamide (10 mg/kg/d) decreases pressor response to oxotremorine, noradrenaline, and tyramine in rats.Animal Model:Male spontaneously hypertensive rats (11 weeks)
Dosage:1 mg/kg
Administration:Gastric gavage per day for 8 weeks
Result:Decreased blood pressure by 16.9 mm Hg.Increased the dp/dtmax, ejection fraction (EF) and fractional shortening (FS).
体外研究：
Indapamide (0.1-500 mg/L; 20min) reduces total insulin secretory response to glucose infusions in isolated perfused rat pancreas.Indapamide (1-100 μM) increases osteoblast proliferation and decreased bone resorption.
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