产品
编 号：F298960
分子式：C15H12O2
分子量：224.25
分子式：C15H12O2
分子量：224.25
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5g
400
In-stock
结构图
CAS No: 2657-25-2
产品详情
生物活性：
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
体内研究：
4'-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice.Animal Model:Male albino mice(5-30 g)
Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:Oral administration, 12h intervals, 4 doses
Result:Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg).
体外研究：
4'-Hydroxychalcone (20-40 μM ; 2 hours) inhibits TNFα-induced (20 ng/mL; 6 hours) NF-kB pathway activation in a dose-dependent manner.4'-Hydroxychalcone (0.1-25 μM ; 8 hours) inhibits proteasome activity in a dose-dependent manner but has no effect on IKK activity.4'-Hydroxychalcone inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 4'-Hydroxychalcone-inhibited expression of NF-kB target genes.4'-Hydroxychalcone affects cancer cell viability but has no significant effect on non-transformed cell viability.
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
体内研究：
4'-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice.Animal Model:Male albino mice(5-30 g)
Dosage:25 mg/kg, 50 mg/kg, 100 mg/kg
Administration:Oral administration, 12h intervals, 4 doses
Result:Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg).
体外研究：
4'-Hydroxychalcone (20-40 μM ; 2 hours) inhibits TNFα-induced (20 ng/mL; 6 hours) NF-kB pathway activation in a dose-dependent manner.4'-Hydroxychalcone (0.1-25 μM ; 8 hours) inhibits proteasome activity in a dose-dependent manner but has no effect on IKK activity.4'-Hydroxychalcone inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 4'-Hydroxychalcone-inhibited expression of NF-kB target genes.4'-Hydroxychalcone affects cancer cell viability but has no significant effect on non-transformed cell viability.
产品资料
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