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编 号:F298769
分子式:C37H56F7N6O16P
分子量:1004.83
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CAS No: 265121-04-8
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Fosaprepitant dimeglumine (MK-0517) is a proagent of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV).
体内研究:
Fosaprepitant dimeglumine (30 mg/kg;腹腔注射;每天;持续 7 天) 在大鼠中减弱对吗啡的耐受性并增加抗伤害作用。Animal Model:Sprague-Dawley rats
Dosage:30 mg/kg
Administration:Intraperitoneal injection, daily, for 7 days
Result:Increased the antinociceptive effect of morphine compared to control group.