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编 号：F297903
分子式：C8H8O
分子量：120.15
分子式：C8H8O
分子量：120.15
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CAS No: 2628-17-3
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生物活性：
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.
体外研究：
4-Vinylphenol (12.5-200 μg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 μg/mL. 4-Vinylphenol (0.15 or 0.3 μg/mL; 3 days) reduces sphere?formation and vimentin expression on CSCs in breast cancer. 4-Vinylphenol (50, 100 μg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol (100 μg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis.
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo.
体外研究：
4-Vinylphenol (12.5-200 μg/mL) significantly reduces cell viability in parental MDA-MB-231 cells, and the IC50 value is 109 μg/mL. 4-Vinylphenol (0.15 or 0.3 μg/mL; 3 days) reduces sphere?formation and vimentin expression on CSCs in breast cancer. 4-Vinylphenol (50, 100 μg/mL; 72 hours) significantly suppresses cell proliferation in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol significantly reduces ALDH1A1 expression by 50% in CSC-enriched MDA-MB-231 cells. 4-Vinylphenol (100 μg/mL) significantly increases the expressions of caspase 3, likely sensitizing CSC-enriched MDAMB-231 cells to apoptosis.
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