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编 号：F297800
分子式：C11H10O5
分子量：222.19
分子式：C11H10O5
分子量：222.19
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CAS No: 26246-41-3
产品详情
生物活性：
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma.
体内研究：
Reticulol (10 mg/kg，50 mg/kg；静脉注射；肿瘤植入后第 3 天和第 5 天) 抑制 B16F10 黑色素瘤小鼠的肿瘤生长，并显示肺转移阻断作用。Animal Model:Pathogen-free female C57BL/6J mice
Dosage:10 mg/kg, 50 mg/kg
Administration:IV via the tail vein; day 3 and day 5 after tumor implanted
Result:Inhibited tumor growth.
体外研究：
Reticulol (25-200 μM) 对人肺肿瘤细胞系 A427 和小鼠黑色素瘤细胞系 B16F10 显示出有效的细胞毒性。
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma.
体内研究：
Reticulol (10 mg/kg，50 mg/kg；静脉注射；肿瘤植入后第 3 天和第 5 天) 抑制 B16F10 黑色素瘤小鼠的肿瘤生长，并显示肺转移阻断作用。Animal Model:Pathogen-free female C57BL/6J mice
Dosage:10 mg/kg, 50 mg/kg
Administration:IV via the tail vein; day 3 and day 5 after tumor implanted
Result:Inhibited tumor growth.
体外研究：
Reticulol (25-200 μM) 对人肺肿瘤细胞系 A427 和小鼠黑色素瘤细胞系 B16F10 显示出有效的细胞毒性。
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