产品
编 号：F297791
分子式：C10H17NO5S
分子量：263.31
分子式：C10H17NO5S
分子量：263.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
171
In-stock
10mg
274
In-stock
50mg
540
In-stock
100mg
864
In-stock
结构图
CAS No: 2624-44-4
产品详情
生物活性：
Ethamsylate (Etamsylate) is an orally active anti-hemorrhagic compound. Ethamsylate inhibits biosynthesis and action of prostaglandins. Ethamsylate has the potential to maintain early hemostasis as well as restores capillary resistance. Ethamsylate acts as an antiangiogenic factor, inhibiting wound healing and matrigel tubulogenesis..
体内研究：
Ethamsylate (100 mg/kg, 口服, 一天两次, 3天) 可减弱脊髓损伤小鼠残缺的继发性发病机制，并表现出神经保护作用。Animal Model:C57BL/6J female mice of spinal cord injury
Dosage:100 mg/kg
Administration:Oral gavage (p.o.), twice a day, three days
Result:Attenuated the MMP-9 expression.Inhibited the degradation of TJ proteins.Reduced the upregulation of IL-1β, IL-6, and TNF-α.Reduced axonal demyelination and decreased cystic cavity formation.Reduced the extent of Fibrotic scar formation.
体外研究：
Ethamsylate (480 μM, 30 mim) 延长中性粒细胞的寿命。Ethamsylate (0-100 μM, 3-8 h) 抑制内皮细胞基质上的迁移和小管的形成。Ethamsylate (0-100 μM, 48 h) 抑制 FGF/FGFR 信号通路，降低 AKT 和 Erk1/2 的磷酸化水平。
Ethamsylate (Etamsylate) is an orally active anti-hemorrhagic compound. Ethamsylate inhibits biosynthesis and action of prostaglandins. Ethamsylate has the potential to maintain early hemostasis as well as restores capillary resistance. Ethamsylate acts as an antiangiogenic factor, inhibiting wound healing and matrigel tubulogenesis..
体内研究：
Ethamsylate (100 mg/kg, 口服, 一天两次, 3天) 可减弱脊髓损伤小鼠残缺的继发性发病机制，并表现出神经保护作用。Animal Model:C57BL/6J female mice of spinal cord injury
Dosage:100 mg/kg
Administration:Oral gavage (p.o.), twice a day, three days
Result:Attenuated the MMP-9 expression.Inhibited the degradation of TJ proteins.Reduced the upregulation of IL-1β, IL-6, and TNF-α.Reduced axonal demyelination and decreased cystic cavity formation.Reduced the extent of Fibrotic scar formation.
体外研究：
Ethamsylate (480 μM, 30 mim) 延长中性粒细胞的寿命。Ethamsylate (0-100 μM, 3-8 h) 抑制内皮细胞基质上的迁移和小管的形成。Ethamsylate (0-100 μM, 48 h) 抑制 FGF/FGFR 信号通路，降低 AKT 和 Erk1/2 的磷酸化水平。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备