产品
编 号：F034498
分子式：C34H36FN5O2
分子量：565.68
分子式：C34H36FN5O2
分子量：565.68
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 1094873-14-9
产品详情
生物活性：
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.
体内研究：
JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals.Animal Model:Stressed and nonstressed male Sprague-Dawley rats
Dosage:0, 3, 10 and 20 mg/kg
Administration:Subcutaneous injection; 0-20 mg/kg once
Result:Significantly decreased plasma corticosterone levels in stressed animals, but not significantly affected plasma corticosterone levels in nonstressed animals. Attenuated effects of stress on refeeding.
体外研究：
JNJ-31020028 (0-10 μM) selectively binds with hY2 , rY2 and mY2 with pIC50 values of 8.07, 8.22 and 8.21, respectively.JNJ-31020028 (0.1 nM-10 μM; 1 hour) inhibits PYY-induced calcium response with a pKB value of 8.04.
JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease.
体内研究：
JNJ-31020028 (0-20 mg/kg; s.c. once) affects the level of plasma corticosterone and refeeding result in stressed animals.Animal Model:Stressed and nonstressed male Sprague-Dawley rats
Dosage:0, 3, 10 and 20 mg/kg
Administration:Subcutaneous injection; 0-20 mg/kg once
Result:Significantly decreased plasma corticosterone levels in stressed animals, but not significantly affected plasma corticosterone levels in nonstressed animals. Attenuated effects of stress on refeeding.
体外研究：
JNJ-31020028 (0-10 μM) selectively binds with hY2 , rY2 and mY2 with pIC50 values of 8.07, 8.22 and 8.21, respectively.JNJ-31020028 (0.1 nM-10 μM; 1 hour) inhibits PYY-induced calcium response with a pKB value of 8.04.
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