产品
编 号：F297072
分子式：C15H13N3O2S
分子量：299.35
分子式：C15H13N3O2S
分子量：299.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 26130-02-9
产品详情
生物活性：
Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus.
体内研究：
Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice.Animal Model:NZB/NZW mice
Dosage:8.2 or 79.9 mg/kg/day for young mice
Administration:In animal feedings; 52 weeks
Result:Showed that the average lifespan of young untreated mice was 38 weeks, in the low dose group the average lifespan was about 38 weeks, and in the high dose group the lifespan was significantly longer with an average lifespan of about 61 weeks.Significantly suppressed leukocyte counts, compared to a mean peripheral blood leukocyte count of 4160 in control mice, 3217 in low dose treated mice and 3450 in high dose treated mice.Significant increased in terminal neutrophil counts in young low and high dose treated mice compared to control.
体外研究：
Frentizole (500 ng/mL, 48 hours) is effective in inhibiting thymidine incorporation into DNA when adds to lymphocyte cultures alongside mitogens, and significantly inhibits the response to concanavalin A by 58% in a dose-dependent manner in lymphocytes extracted from mice peritoneal cavity. Frentizole (62.5 ng/mL) can effectively inhibit uridine incorporation and the inhibition of uridine incorporation is independent of the phytochemical used.
Frentizole, an FDA-approved immunosuppressant, is a Aβ-ABAD (binding alcohol dehydrogenase) interaction inhibitor with an IC50 value of 200 μM. Frentizole is used in studies of diseases related to rheumatoid arthritis and systemic lupus erythematosus.
体内研究：
Frentizole (8.2 or 79.9 mg/kg/day for young mice in animal feedings, 52 weeks) can extend the life span of NZB/NZW mice.Animal Model:NZB/NZW mice
Dosage:8.2 or 79.9 mg/kg/day for young mice
Administration:In animal feedings; 52 weeks
Result:Showed that the average lifespan of young untreated mice was 38 weeks, in the low dose group the average lifespan was about 38 weeks, and in the high dose group the lifespan was significantly longer with an average lifespan of about 61 weeks.Significantly suppressed leukocyte counts, compared to a mean peripheral blood leukocyte count of 4160 in control mice, 3217 in low dose treated mice and 3450 in high dose treated mice.Significant increased in terminal neutrophil counts in young low and high dose treated mice compared to control.
体外研究：
Frentizole (500 ng/mL, 48 hours) is effective in inhibiting thymidine incorporation into DNA when adds to lymphocyte cultures alongside mitogens, and significantly inhibits the response to concanavalin A by 58% in a dose-dependent manner in lymphocytes extracted from mice peritoneal cavity. Frentizole (62.5 ng/mL) can effectively inhibit uridine incorporation and the inhibition of uridine incorporation is independent of the phytochemical used.
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