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编 号：F295916
分子式：C17H30Br2N2
分子量：422.24
分子式：C17H30Br2N2
分子量：422.24
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CAS No: 258282-23-4
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生物活性：
IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy.
体内研究：
IEM-1925 (10 mg/kg) 减弱了大鼠癫痫状态下的行为运动惊厥症状，将Pinel和Rovner评分中的癫痫发作强度从8分降至4分。Animal Model:Rats (males, weight 240-350 g).
Dosage:5, 10 mg/kg.
Administration:i.m.
Result:Administration of 5 and 10 mg/kg IEM-1925 2 h before pilocarpine did not alter the overall SE pattern. However, IEM-1925 significantly changed the latent periods of onset and durations of the separate phases and also decreased the total duration of status.
IEM-1925 bromide is an orally active glutamate receptor antagonist, increases the latent period and decreases the duration of status epilepticus in rats in a lithium-pilocarpine model of epilepsy.
体内研究：
IEM-1925 (10 mg/kg) 减弱了大鼠癫痫状态下的行为运动惊厥症状，将Pinel和Rovner评分中的癫痫发作强度从8分降至4分。Animal Model:Rats (males, weight 240-350 g).
Dosage:5, 10 mg/kg.
Administration:i.m.
Result:Administration of 5 and 10 mg/kg IEM-1925 2 h before pilocarpine did not alter the overall SE pattern. However, IEM-1925 significantly changed the latent periods of onset and durations of the separate phases and also decreased the total duration of status.
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