产品
编 号：F295609
分子式：C19H21NO5S
分子量：375.44
分子式：C19H21NO5S
分子量：375.44
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 257292-29-8
产品详情
生物活性：
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.
体内研究：
KF38789 can block P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.Intraperitoneal injection of the P-selectin inhibitor KF38789 (daily intraperitoneal injection of 10mg/kg for 12 days) significantly reduces mechanical allodynia in the facial carrageenan-injected mice.Animal Model:BALB/c mice
Dosage:1 mg/kg
Administration:Intravenously administrated
Result:Significantly reduced leukocyte accumulation.
Animal Model:Twenty-four adult male C57BL/6J (B6) mice, about 6-8 weeks of age and weighing approximately 20-30 g
Dosage:10 mg/kg, 1 mg/kg, 0.1 mg/kg, 0.01 mg/kg or 0.001 mg/kg
Administration:Intraperitoneal injection daily for 12 days
Result:Significantly reduced mechanical allodynia in the facial carrageenan-injected mice.
体外研究：
KF38789 inhibits P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF38789 significantly inhibits the thioglycollate (TG)-induced accumulation of leukocytes in the mouse peritoneal cavity.KF38789 displays a concentration-dependent inhibition of U937 cell adhesion to immobilized P-selectin-Ig with an IC50 value of 1.97±0.74 μM.KF38789 specifically inhibits P-selectin-dependent cell adhesion and the leukocyte recruitment in mouse peritonitis.KF38789 (5?μM) significantly reduces closure of a 500-μm gap between confluent sheets of Human corneal epithelial (HCE)-T cells over an 8-hr period (by ～40%).Corneal epithelial cell migration is reduced in the presence of KF38789 (5?μM) .
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.
体内研究：
KF38789 can block P-selectin-mediated binding in vitro and leukocyte accumulation in vivo.Intraperitoneal injection of the P-selectin inhibitor KF38789 (daily intraperitoneal injection of 10mg/kg for 12 days) significantly reduces mechanical allodynia in the facial carrageenan-injected mice.Animal Model:BALB/c mice
Dosage:1 mg/kg
Administration:Intravenously administrated
Result:Significantly reduced leukocyte accumulation.
Animal Model:Twenty-four adult male C57BL/6J (B6) mice, about 6-8 weeks of age and weighing approximately 20-30 g
Dosage:10 mg/kg, 1 mg/kg, 0.1 mg/kg, 0.01 mg/kg or 0.001 mg/kg
Administration:Intraperitoneal injection daily for 12 days
Result:Significantly reduced mechanical allodynia in the facial carrageenan-injected mice.
体外研究：
KF38789 inhibits P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF38789 significantly inhibits the thioglycollate (TG)-induced accumulation of leukocytes in the mouse peritoneal cavity.KF38789 displays a concentration-dependent inhibition of U937 cell adhesion to immobilized P-selectin-Ig with an IC50 value of 1.97±0.74 μM.KF38789 specifically inhibits P-selectin-dependent cell adhesion and the leukocyte recruitment in mouse peritonitis.KF38789 (5?μM) significantly reduces closure of a 500-μm gap between confluent sheets of Human corneal epithelial (HCE)-T cells over an 8-hr period (by ～40%).Corneal epithelial cell migration is reduced in the presence of KF38789 (5?μM) .
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