产品
编 号：F295210
分子式：C20H10F6N2OS
分子量：440.36
分子式：C20H10F6N2OS
分子量：440.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
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询价
10mg
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询价
结构图
CAS No: 256414-75-2
产品详情
生物活性：
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
体内研究：
SEW2871 (20 mg/kg，管饲，每天一次，持续 2 周) 改善 IL-10–/– 小鼠中已建立的实验性结肠炎。 SEW2871 (0.5 mg/kg，IP，每日一次，持续 2 周) 抑制阿尔茨海默病大鼠模型中的 β 淀粉样蛋白 (Aβ1-42) 诱导的空间记忆障碍和海马神经元丢失。 SEW2871 (0-0.3 mg/kg，静脉注射) 减轻 LPS 诱导的急性炎症性肺损伤，在 C57Bl/6 小鼠中产生剂量依赖性肺泡和血管屏障保护。 SEW2871 通过减少小鼠体内的 CD4+ T 细胞浸润，有效保护肾脏免受缺血再灌注损伤。Animal Model:IL-10–/– (interleukin (IL)-10 gene-deficient) mice, a murine model of Crohn's disease (CD)
Dosage:20 mg/kg
Administration:Gavage, once daily for 2 weeks
Result:Ameliorated established colitis in IL-10–/– mice, associated with a reduction of serum amyloid A concentration, a decreased colon MPO concentration, a depletion of the peripheral CD4+CD45+ T cells and a reduction of the homing of T cells into colon LP. Suppressed typical cytokines of T helper type 1 (Th1) and Th17 cells and p-STAT-3 expression, and significantly decreased TNF-α, IFN-γ, IL-1β and IL-17A mRNA levels.
体外研究：
SEW2871 通过增加 LX-2 细胞 (一种人肝星状细胞系) 中的平滑肌 α-肌动蛋白、前胶原 αI 和 αIII 以及总羟脯氨酸含量发挥强大的迁移作用。
SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. SEW2871 reduces lymphocyte numbers in blood. SEW2871 can be used for the research of diabetes, Alzheimer’s disease, liver fibrosis, and inflammatory responses.
体内研究：
SEW2871 (20 mg/kg，管饲，每天一次，持续 2 周) 改善 IL-10–/– 小鼠中已建立的实验性结肠炎。 SEW2871 (0.5 mg/kg，IP，每日一次，持续 2 周) 抑制阿尔茨海默病大鼠模型中的 β 淀粉样蛋白 (Aβ1-42) 诱导的空间记忆障碍和海马神经元丢失。 SEW2871 (0-0.3 mg/kg，静脉注射) 减轻 LPS 诱导的急性炎症性肺损伤，在 C57Bl/6 小鼠中产生剂量依赖性肺泡和血管屏障保护。 SEW2871 通过减少小鼠体内的 CD4+ T 细胞浸润，有效保护肾脏免受缺血再灌注损伤。Animal Model:IL-10–/– (interleukin (IL)-10 gene-deficient) mice, a murine model of Crohn's disease (CD)
Dosage:20 mg/kg
Administration:Gavage, once daily for 2 weeks
Result:Ameliorated established colitis in IL-10–/– mice, associated with a reduction of serum amyloid A concentration, a decreased colon MPO concentration, a depletion of the peripheral CD4+CD45+ T cells and a reduction of the homing of T cells into colon LP. Suppressed typical cytokines of T helper type 1 (Th1) and Th17 cells and p-STAT-3 expression, and significantly decreased TNF-α, IFN-γ, IL-1β and IL-17A mRNA levels.
体外研究：
SEW2871 通过增加 LX-2 细胞 (一种人肝星状细胞系) 中的平滑肌 α-肌动蛋白、前胶原 αI 和 αIII 以及总羟脯氨酸含量发挥强大的迁移作用。
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