产品
编 号：F295204
分子式：C25H27N3O4
分子量：433.5
分子式：C25H27N3O4
分子量：433.5
产品类型
规格
价格
是否有货
结构图
CAS No: 256411-32-2
产品详情
生物活性：
Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer.
体内研究：
Belotecan (25 mg/kg; i.v. for 16 days at 4-day intervals) inhibits tumor growth in CaSki-xenografts nude mice.Animal Model:BALB/c-nude mice with CaSki cells injection
Dosage:25 mg/kg
Administration:Intravenous injection; 25 mg/kg; 16 days at 4-day intervals
Result:Significantly inhibited the tumor growth and showed no significant difference in bodyweight of xenograft mice and the controls.
体外研究：
Belotecan (0-600 ng/mL; 0-72 h) time- and dose-dependently inhibits viability of Caski cells, HeLa cells and SiHa cells at 48 h with IC50 values of 30, 150 and 150 ng/mL, respectively.Belotecan (0-150 ng/mL; 48 h) induces cell apoptosis and cell-cycle arrest, and affects PARP, cleaved PARP, BAX, p53, Ser15, cell cycle related protein expression and cancer invasion in cervical cancer.
Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer.
体内研究：
Belotecan (25 mg/kg; i.v. for 16 days at 4-day intervals) inhibits tumor growth in CaSki-xenografts nude mice.Animal Model:BALB/c-nude mice with CaSki cells injection
Dosage:25 mg/kg
Administration:Intravenous injection; 25 mg/kg; 16 days at 4-day intervals
Result:Significantly inhibited the tumor growth and showed no significant difference in bodyweight of xenograft mice and the controls.
体外研究：
Belotecan (0-600 ng/mL; 0-72 h) time- and dose-dependently inhibits viability of Caski cells, HeLa cells and SiHa cells at 48 h with IC50 values of 30, 150 and 150 ng/mL, respectively.Belotecan (0-150 ng/mL; 48 h) induces cell apoptosis and cell-cycle arrest, and affects PARP, cleaved PARP, BAX, p53, Ser15, cell cycle related protein expression and cancer invasion in cervical cancer.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备