产品
编 号：F033485
分子式：C18H23NO5
分子量：333.38
分子式：C18H23NO5
分子量：333.38
产品类型
规格
价格
是否有货
结构图
CAS No: 109351-36-2
产品详情
生物活性：
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor.
体内研究：
Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) decreases the morbidity and increases the survival of severely DENV-infected AG129 mice, with no body weight change.Animal Model:AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection
Dosage:0.5, 1.0, 2.0 mg/kg/day
Administration:I.p. twice a day for 5 days
Result:Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day. The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.
体外研究：
Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells.Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively.
Sinococuline is a potent anti-dengue agent that is effective against all four serotypes of dengue virus (DENV). Sinococuline is also an effective tumor cell growth inhibitor.
体内研究：
Sinococuline (0.5-2.0 mg/kg/day; i.p. twice a day for 5 days) decreases the morbidity and increases the survival of severely DENV-infected AG129 mice, with no body weight change.Animal Model:AG129 mouse (an interferon type I and II receptor-deficient mice) with severe DENV-infection
Dosage:0.5, 1.0, 2.0 mg/kg/day
Administration:I.p. twice a day for 5 days
Result:Showed delayed mortality and survived significantly of mice, but none of the mice could survive till the end of experiment at the dose of 0.5 mg/kg/day. The mice completely survived through the entire course of experiment at the dose of 2.0 mg/kg/day.
体外研究：
Sinococuline (0.5-5.0 μg/mL; 6 days) inhibits the non-structural protein-1 (NS1) release by DENV-2 infected Vero cells.Sinococuline (0-40 μg/mL; 48 h) inhibits pan-DENV infection in Vero cells, with IC50s of 0.2, 0.08, 0.17, and 0.1 μg/mL for DENV-1, DENV-2, DENV-3, and DENV-4, respectively.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备