产品
编 号：F294379
分子式：C14H23NO
分子量：221.34
分子式：C14H23NO
分子量：221.34
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CAS No: 25394-57-4
产品详情
生物活性：
Spilanthol is an orally active analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial and insecticidal compound.pilanthol can induce cAMP to inhibit negative regulation of urinary concentration mechanism. Spilanthol can be use as diuretic research.
体内研究：
Spilanthol ( 1-1.875 mg/kg, Ip, Once) 在醋酸导致腹部扭动和辣椒素导致舔爪雄性 ICR 小鼠模型具有镇痛的作用。Spilanthol (30 mg/kg, 口服, 一天一次共4天) 在 5-氟尿嘧啶 (HY-90006) 致瑞士小鼠肠道黏膜炎模型对肠道损伤有保护作用。Spilanthol (800 mg/kg, 口服, 给药一次) 在成年 C57BL/6J 雄性小鼠中具有利尿的作用。Animal Model:Acetic acid-induced abdominal writhes Male ICR mice model
Dosage:1-1.875 mg/kg
Administration:Intraperitoneal administration(i.p.), Once
Result:As the dose increased, the number of abdominal contractions and licking behavior decreased, and a maximum antinociceptive effect of 46.67%
Animal Model:Swiss mice model of intestinal mucositis induced by 5-fluorouracil.
Dosage:30 mg/kg
Administration:Oral adminstraion(p.o.), Once a day for four days
Result:Showed the intestinal wall recovery, villi are higher and less irregularity and high number and greater length of intestinal crypts.
Animal Model:Adult C57BL/6J male mice.
Dosage:800 mg/Kg
Administration:Oral adminstraion (p.o.), Once
Result:Increased in urine output, sodium, and increased excretion of sodium, potassium and chloride.
体外研究：
Spilanthol (50~150 μM, 24h) 对 A549 人肺上皮细胞活力无影响。Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系具有抗炎的作用。Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系中能降低 ICAM-1 基因的表达。
Spilanthol is an orally active analgesic, neuroprotective, antioxidant, antimutagenic, anti-cancer, anti-inflammatory, antimicrobial and insecticidal compound.pilanthol can induce cAMP to inhibit negative regulation of urinary concentration mechanism. Spilanthol can be use as diuretic research.
体内研究：
Spilanthol ( 1-1.875 mg/kg, Ip, Once) 在醋酸导致腹部扭动和辣椒素导致舔爪雄性 ICR 小鼠模型具有镇痛的作用。Spilanthol (30 mg/kg, 口服, 一天一次共4天) 在 5-氟尿嘧啶 (HY-90006) 致瑞士小鼠肠道黏膜炎模型对肠道损伤有保护作用。Spilanthol (800 mg/kg, 口服, 给药一次) 在成年 C57BL/6J 雄性小鼠中具有利尿的作用。Animal Model:Acetic acid-induced abdominal writhes Male ICR mice model
Dosage:1-1.875 mg/kg
Administration:Intraperitoneal administration(i.p.), Once
Result:As the dose increased, the number of abdominal contractions and licking behavior decreased, and a maximum antinociceptive effect of 46.67%
Animal Model:Swiss mice model of intestinal mucositis induced by 5-fluorouracil.
Dosage:30 mg/kg
Administration:Oral adminstraion(p.o.), Once a day for four days
Result:Showed the intestinal wall recovery, villi are higher and less irregularity and high number and greater length of intestinal crypts.
Animal Model:Adult C57BL/6J male mice.
Dosage:800 mg/Kg
Administration:Oral adminstraion (p.o.), Once
Result:Increased in urine output, sodium, and increased excretion of sodium, potassium and chloride.
体外研究：
Spilanthol (50~150 μM, 24h) 对 A549 人肺上皮细胞活力无影响。Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系具有抗炎的作用。Spilanthol (50~150 μM, 24h) 在 A549 人肺上皮细胞系中能降低 ICAM-1 基因的表达。
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