产品
编 号：F033440
分子式：C26H24N6O2S2
分子量：516.64
分子式：C26H24N6O2S2
分子量：516.64
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
50mg
询价
询价
100mg
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询价
结构图
CAS No: 1093403-33-8
产品详情
生物活性：
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.
体内研究：
SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice.SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice.SRT 2104 (0.5%; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice.Animal Model:Male C57BL/6 mice (8-week-old)
Dosage:100 mg/kg/day
Administration:Supplemented in diet for 24 weeks
Result:Enhanced SIRT1 protein without evelating Sirt1 mRNA level. Attenuated diabetes mellitus (DM)-induced oxidative stress, apoptotic signaling, and ER stress.
Animal Model:WT and N171-82Q HD mice (6 weeks old)
Dosage:0.5%
Administration:0.5% SRT 2104 containing diet for 6, 12, 18 weeks
Result:Ameliorated motor deficits and increased survival in N171-82Q HD mice.
SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntington’s disease.
体内研究：
SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) increases SIRT1 protein without altering Sirt1 mRNA in diabetic mice.SRT 2104 (100 mg/kg/day, supplemented in diet for 24 weeks) decreases testicular oxidative stress, activation of apoptotic signaling, and ER stress in diabetic mice.SRT 2104 (0.5%; for 18 weeks) improves motor function and increases survival in N171-82Q HD mice.Animal Model:Male C57BL/6 mice (8-week-old)
Dosage:100 mg/kg/day
Administration:Supplemented in diet for 24 weeks
Result:Enhanced SIRT1 protein without evelating Sirt1 mRNA level. Attenuated diabetes mellitus (DM)-induced oxidative stress, apoptotic signaling, and ER stress.
Animal Model:WT and N171-82Q HD mice (6 weeks old)
Dosage:0.5%
Administration:0.5% SRT 2104 containing diet for 6, 12, 18 weeks
Result:Ameliorated motor deficits and increased survival in N171-82Q HD mice.
产品资料
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