产品
编 号：F293285
分子式：C18H20N4O
分子量：308.38
分子式：C18H20N4O
分子量：308.38
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 251945-92-3
产品详情
生物活性：
Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.
体内研究：
Derenofylline (0.3-10 mg/kg，oral administration) 抑制腺苷诱导的大鼠心动过缓。 Derenofylline (10 mg/kg/d，oral administration，12 weeks) 5/6 肾切除大鼠中减少心肌纤维化，且不影响血压。 Derenofylline (0.1-5mg/kg，静脉注射) 不会引起主要的血液动力学影响 (心率和血压)。Animal Model:5/6 nephrectomy rats
Dosage:10 mg/kg/d
Administration:Oral administration, mixed with food for 12 weeks
Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.
体外研究：
Derenofylline (100 μM，72 h) 抑制 TGF-β1 诱导的肌成纤维细胞转化而不影响细胞活力。
Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats.
体内研究：
Derenofylline (0.3-10 mg/kg，oral administration) 抑制腺苷诱导的大鼠心动过缓。 Derenofylline (10 mg/kg/d，oral administration，12 weeks) 5/6 肾切除大鼠中减少心肌纤维化，且不影响血压。 Derenofylline (0.1-5mg/kg，静脉注射) 不会引起主要的血液动力学影响 (心率和血压)。Animal Model:5/6 nephrectomy rats
Dosage:10 mg/kg/d
Administration:Oral administration, mixed with food for 12 weeks
Result:Attenuated urinary albuminuria by about 50%.Suppressed the increase in CK levels, ALT and AST plasma levels in nephrectomized animals.
体外研究：
Derenofylline (100 μM，72 h) 抑制 TGF-β1 诱导的肌成纤维细胞转化而不影响细胞活力。
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