产品
编 号：F293115
分子式：C24H28N4O3S
分子量：452.57
分子式：C24H28N4O3S
分子量：452.57
产品类型
规格
价格
是否有货
结构图
CAS No: 251577-09-0
产品详情
生物活性：
FTI-2148 is a RAS C-terminal mimetic dual?farnesyl transferase (FT-1)?and?geranylgeranyl transferase-1 (GGT-1)?inhibitor with?IC50s of 1.4 nM and 1.7 μM, respectively.
体内研究：
FTI-2148 (intraperitoneal?injection; 25 or 50 mpk/day with a mini-pump; started on day 15 and stopped on day 45 and restarted day 53-83) inhibits the tumor growth by 91% inhuman lung adenocarcinoma A-549 cells induced mouse model.FTI-2148 (subcutaneous injection; 25 mpk/day with a mini-pump; 14 days) inhibitstumor growth by 77%by the end of the 2-week treatment in Human Xenograft Nude Mouse Model.FTI-2148 (subcutaneous?injection; 100 mg/kg/day; 14 days) results in breast tumor regression in a?ras?transgenic mouse model.FTI-2148 (subcutaneous?injection; 100 mg/kg/day; 4 days) results in 85–88% inhibition of FTase with no inhibition of GGTase I enzymatic activity in breast tumors from mice in vivo?settings.Animal Model:Ras?transgenic mouse model
Dosage:100 mg/kg/day
Administration:Subcutaneous?injection; 100 mg/kg/day; 14 days
Result:Induced regression by 87 ± 3% of mammary carcinomas in mice.
体外研究：
FTI-2148 (30 μM) inhibits the farnesylation of the exclusively farnesylated protein HDJ2 in all 3 RAS-transformed NIH3T3 cells.FTI-2148 is against P. falciparum PFT, Mammalian PFT and Mammalian PGGT-I with IC50 values of 15 nM; 0.82 nM and 1700 nM, respectively. PFT:protein farnesyltransferase; PGGT-I geranylgeranyltransferase-I.
FTI-2148 is a RAS C-terminal mimetic dual?farnesyl transferase (FT-1)?and?geranylgeranyl transferase-1 (GGT-1)?inhibitor with?IC50s of 1.4 nM and 1.7 μM, respectively.
体内研究：
FTI-2148 (intraperitoneal?injection; 25 or 50 mpk/day with a mini-pump; started on day 15 and stopped on day 45 and restarted day 53-83) inhibits the tumor growth by 91% inhuman lung adenocarcinoma A-549 cells induced mouse model.FTI-2148 (subcutaneous injection; 25 mpk/day with a mini-pump; 14 days) inhibitstumor growth by 77%by the end of the 2-week treatment in Human Xenograft Nude Mouse Model.FTI-2148 (subcutaneous?injection; 100 mg/kg/day; 14 days) results in breast tumor regression in a?ras?transgenic mouse model.FTI-2148 (subcutaneous?injection; 100 mg/kg/day; 4 days) results in 85–88% inhibition of FTase with no inhibition of GGTase I enzymatic activity in breast tumors from mice in vivo?settings.Animal Model:Ras?transgenic mouse model
Dosage:100 mg/kg/day
Administration:Subcutaneous?injection; 100 mg/kg/day; 14 days
Result:Induced regression by 87 ± 3% of mammary carcinomas in mice.
体外研究：
FTI-2148 (30 μM) inhibits the farnesylation of the exclusively farnesylated protein HDJ2 in all 3 RAS-transformed NIH3T3 cells.FTI-2148 is against P. falciparum PFT, Mammalian PFT and Mammalian PGGT-I with IC50 values of 15 nM; 0.82 nM and 1700 nM, respectively. PFT:protein farnesyltransferase; PGGT-I geranylgeranyltransferase-I.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备