产品
编 号：F033357
分子式：C25H26F3N5O3
分子量：501.5
分子式：C25H26F3N5O3
分子量：501.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 1093108-50-9
产品详情
生物活性：
BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has potential for the treatment of poorly controlled asthma.
体内研究：
BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice. BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals.Animal Model:6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally).
Dosage:10-0.1 mg/kg
Administration:Oral gavage for 4 weeks
Result:Shows significant inhibition of AHR in mice.
体外研究：
BI-671800 (compound A) exhibits low nM potency as an antagonist of human or mouse CRTH2 in transfected cells.
BI-671800 is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2), with IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2 transfected cells, respectively. BI-671800 has potential for the treatment of poorly controlled asthma.
体内研究：
BI-671800 (compound A, 0.1-10 mg/kg, i.g.) shows significant inhibition of AHR in mice. BI-671800 (compound A), effectively blocks edema formation and greatly reduces the inflammatory infiltrate and skin pathology observed in drug vehicle-treated animals.Animal Model:6-8-week-old age- and sex-matched BALB/c mice (mice were sensitized for 14 days, challenged intranasally).
Dosage:10-0.1 mg/kg
Administration:Oral gavage for 4 weeks
Result:Shows significant inhibition of AHR in mice.
体外研究：
BI-671800 (compound A) exhibits low nM potency as an antagonist of human or mouse CRTH2 in transfected cells.
产品资料
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