产品
编 号：F291989
分子式：C45H76N2O15
分子量：885.09
分子式：C45H76N2O15
分子量：885.09
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
200mg
询价
询价
结构图
CAS No: 24916-51-6
产品详情
生物活性：
Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection.
体内研究：
Acetylspiramycin (25-200 mg/kg/day; 口服; 7 天) 能显著增强 CBA/H 小鼠对 PHA 的淋巴细胞增殖反应，呈剂量依赖性地降低淋巴因子的活性。Acetylspiramycin (50-200 mg/kg/day; 口服; 14 天) 在 CBA/H 小鼠模型中能够增加小鼠体内吞噬作用的效率。Animal Model:CBA/H mice
Dosage:25-200 mg/kg/day
Administration:Oral gavage (p.o.), 7 days
Result:Decreased lymphokine activity in a dose-dependent manner
Animal Model:CBA/H mice
Dosage:50-200 mg/kg/day
Administration:Oral gavage (p.o.), 14 days
Result:Increased the efficiency of phagocytosis in mice.
体外研究：
Acetylspiramycin (0-40 μg/mL, 0-72 小时) 在加入植物血凝素 (PHA, 10 μg/mL) 的脾细胞培养液呈时间和剂量依赖性抑制淋巴细胞的增殖反应。Acetylspiramycin (25 - 100 μg/ml, 18 小时) 能降低小鼠腹腔巨噬细胞的吞噬能力，在体外对巨噬细胞具有可逆的毒性。
Acetylspiramycin (Spiramycin B) is an effective oral macrolide antibiotic produced by Streptomyces, It can inhibit the splenic lymphocyte transformation induced by phytohemagglutinin (PHA), LPS (HY-D1056) and antigen, reduce the procoagulant activity of macrophages, have good antibacterial effect on gram-positive bacteria, and is also an effective antigenic insect agent, which can be used to fight parasitic infection.
体内研究：
Acetylspiramycin (25-200 mg/kg/day; 口服; 7 天) 能显著增强 CBA/H 小鼠对 PHA 的淋巴细胞增殖反应，呈剂量依赖性地降低淋巴因子的活性。Acetylspiramycin (50-200 mg/kg/day; 口服; 14 天) 在 CBA/H 小鼠模型中能够增加小鼠体内吞噬作用的效率。Animal Model:CBA/H mice
Dosage:25-200 mg/kg/day
Administration:Oral gavage (p.o.), 7 days
Result:Decreased lymphokine activity in a dose-dependent manner
Animal Model:CBA/H mice
Dosage:50-200 mg/kg/day
Administration:Oral gavage (p.o.), 14 days
Result:Increased the efficiency of phagocytosis in mice.
体外研究：
Acetylspiramycin (0-40 μg/mL, 0-72 小时) 在加入植物血凝素 (PHA, 10 μg/mL) 的脾细胞培养液呈时间和剂量依赖性抑制淋巴细胞的增殖反应。Acetylspiramycin (25 - 100 μg/ml, 18 小时) 能降低小鼠腹腔巨噬细胞的吞噬能力，在体外对巨噬细胞具有可逆的毒性。
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