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编 号:F291949
分子式:C43H46F3N7O7S
分子量:861.93
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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50mg
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GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent agent resistance. GMB-475 targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel Lindau (VHL), resulting in ubiquitination and subsequent degradation of the oncogenic fusion protein.
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