产品
编 号：F291169
分子式：C34H67NO3
分子量：537.9
分子式：C34H67NO3
分子量：537.9
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 24696-26-2
产品详情
生物活性：
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding.
体外研究：
C16-Ceramide interacts with p53 within its core domain. p53 forms complex with natural C16-Ceramide in the cell.C16-Ceramide (2.5-50 μM; 0-48 h) strongly decreased HCT116 cell viability in a time- and concentration-dependent manner.C16-Ceramide (12 μM; 48 h) induces apoptosis through Btf (Bcl-2-associated transcription factor) in HCT116 cells.C16-ceramide (12 μM; 0-6 h) and Btf expression up-regulate p53 and BAX expression. C16-ceramide down-regulates Mdm2 expression via Btf.
C16-Ceramide is a natural small molecule activating p53 through the direct and selective binding.
体外研究：
C16-Ceramide interacts with p53 within its core domain. p53 forms complex with natural C16-Ceramide in the cell.C16-Ceramide (2.5-50 μM; 0-48 h) strongly decreased HCT116 cell viability in a time- and concentration-dependent manner.C16-Ceramide (12 μM; 48 h) induces apoptosis through Btf (Bcl-2-associated transcription factor) in HCT116 cells.C16-ceramide (12 μM; 0-6 h) and Btf expression up-regulate p53 and BAX expression. C16-ceramide down-regulates Mdm2 expression via Btf.
产品资料
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