产品
编 号：F290468
分子式：C12H15N3O6
分子量：297.26
分子式：C12H15N3O6
分子量：297.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
500mg
400
In-stock
1g
600
In-stock
结构图
CAS No: 2451-62-9
产品详情
生物活性：
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.
体内研究：
Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice.Animal Model:Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area
Dosage:1.8mg/kg and 3.6 mg/kg
Administration:Subcutaneous injection; every 2–3 days for total seven times; 30 days
Result:Inhibited the growth of xenograft tumors.
体外研究：
Triglycidyl isocyanurate?(0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472?of A549, H460 and H1299 tumorspheres, however, the?cleavage?of PARP and?procaspase-3?plus the emergent active?caspase-3?fragment are only visible in H460 and A549 tumorspheres.
Triglycidyl isocyanurate (TGIC; Teroxirone) is a triazene triepoxide with antiangiogenic and antineoplastic activities. Triglycidyl isocyanurate inhibits the growth of non-small-cell-lung cancer cells via?p53 activation. Triglycidyl isocyanurate induces cell apoptosis. Triglycidyl isocyanurate can be used for cancer research.
体内研究：
Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days) suppresses the growth of xenograft tumors and has no effects on weight in nude mice.Animal Model:Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area
Dosage:1.8mg/kg and 3.6 mg/kg
Administration:Subcutaneous injection; every 2–3 days for total seven times; 30 days
Result:Inhibited the growth of xenograft tumors.
体外研究：
Triglycidyl isocyanurate?(0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells.Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472?of A549, H460 and H1299 tumorspheres, however, the?cleavage?of PARP and?procaspase-3?plus the emergent active?caspase-3?fragment are only visible in H460 and A549 tumorspheres.
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