产品
编 号：F290232
分子式：C11H8N2
分子量：168.2
分子式：C11H8N2
分子量：168.2
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
160
In-stock
结构图
CAS No: 244-63-3
产品详情
生物活性：
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
体内研究：
Norharmane (0-10 mg/kg，IP，一次) 表现出焦虑和抗抑郁样行为，并降低运动活动。Animal Model:Male NMRI mice (22-25?g)
Dosage:0, 2.5, 5 and 10?mg/kg
Administration:IP, once
Result:Elicited an anxiety- and antidepressant-like behavior, and decreased locomotor activity.
体外研究：
Norharmane 通过干扰素-γ 刺激的单核细胞 THP-1 细胞减弱喹啉酸的形成并减弱 L-犬尿氨酸的形成，IC50 值分别为 51 μM 和 43 μM。 Norharmane 有潜力用作抗生素佐剂，以增强常规抗生素的功效，以减少致病性细菌感染。
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
体内研究：
Norharmane (0-10 mg/kg，IP，一次) 表现出焦虑和抗抑郁样行为，并降低运动活动。Animal Model:Male NMRI mice (22-25?g)
Dosage:0, 2.5, 5 and 10?mg/kg
Administration:IP, once
Result:Elicited an anxiety- and antidepressant-like behavior, and decreased locomotor activity.
体外研究：
Norharmane 通过干扰素-γ 刺激的单核细胞 THP-1 细胞减弱喹啉酸的形成并减弱 L-犬尿氨酸的形成，IC50 值分别为 51 μM 和 43 μM。 Norharmane 有潜力用作抗生素佐剂，以增强常规抗生素的功效，以减少致病性细菌感染。
产品资料
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