产品
编 号:F290145
分子式:C22H16F4N4OS
分子量:460.45
产品类型
结构图
CAS No: 2443816-45-1
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产品详情
生物活性:
ULK-101 is a potent and selective ULK1 inhibitor, with IC50 values of 1.6 nM and 30 nM for ULK1 and ULK2, respectively. ULK-101 suppresses autophagy and sensitizes cancer cells to nutrient stress.
体外研究:
ULK-101 (0-5 μM) reduces BafA1-induced LC3B-II accumulation in U2OS cells in a concentration-dependent manner.