产品
编 号：F289959
分子式：C27H22BrNO4S
分子量：536.44
分子式：C27H22BrNO4S
分子量：536.44
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 244101-02-8
产品详情
生物活性：
L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has ?micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM, respectively.
体内研究：
L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 w) suppresses systemic insulin resistance and AT inflammation in db/db mice.Animal Model:Male db/db mice
Dosage:50 and 100 μg/kg
Administration:Oral gavage; 50 and 100 μg/kg; once daily; 8 weeks
Result:Suppressed the increased fasting blood glucose levels in the db/db mice.Suppressed increased proinflammatory gene expressions in the adipocytes isolated from the epididymal AT of the db/db mice.
体外研究：
L-798106 (200 nM) inhibits electrical field stimulation-induced contractile responses.L-798106 (10 μM) inhibits electrical field stimulation-evoked ACh release.
L-798106 is potent and highly selective prostanoid EP3 receptor antagonist (Ki=0.3 nM), it also has ?micromolar activities at the EP4, EP1 and EP2 receptors with Ki values of 916 nM, >5000 nM and >5000 nM, respectively.
体内研究：
L-798106 (oral gavage; 50 and 100 μg/kg; once daily; 8 w) suppresses systemic insulin resistance and AT inflammation in db/db mice.Animal Model:Male db/db mice
Dosage:50 and 100 μg/kg
Administration:Oral gavage; 50 and 100 μg/kg; once daily; 8 weeks
Result:Suppressed the increased fasting blood glucose levels in the db/db mice.Suppressed increased proinflammatory gene expressions in the adipocytes isolated from the epididymal AT of the db/db mice.
体外研究：
L-798106 (200 nM) inhibits electrical field stimulation-induced contractile responses.L-798106 (10 μM) inhibits electrical field stimulation-evoked ACh release.
产品资料
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