产品
编 号：F289813
分子式：C6H12O5
分子量：164.16
分子式：C6H12O5
分子量：164.16
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
50mg
258
In-stock
100mg
400
In-stock
结构图
CAS No: 2438-80-4
产品详情
生物活性：
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth.
体内研究：
(-)-Fucose (100mg，腹腔注射，单或双剂量) 阻断 CL-11 相关补体 C3d 在缺氧肾小管细胞上的沉积，揭示了对 C57BL/6 小鼠中具有 CL11 依赖性的 I/R 损伤的保护作用。(-)-Fucose (1-5 g/kg/d，腹腔注射，11 天) 在携带 SET 肿瘤的 NMRI 小鼠体内可以抑制肿瘤生长和有丝分裂活性，促进肿瘤转移。Animal Model:CL11+/+ and CL11-/- C57BL/6 mice
Dosage:100 mg
Administration:intraperitoneal injection, 1 h before ischemia induction or 1 h prior and a secong dose immediately following reperfusion.
Result:Decreased C3d deposition in CL+/+ C57BL/6 mice.
Animal Model:SET bearing NMRI mice
Dosage:1-5 g/kg
Administration:intraperitoneal injection, once everyday for 11 days.
Result:Inhibited tumor growth, induced tumor metastasis.
体外研究：
(-)-Fucose (8-80 mM) 抑制 CL-11 与固定配体的结合并消除补体激活的触发因素，IC50 为 12.2 mM。
(-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. (-)-Fucose is orally active, inhibits CL11-induced inflammatory response in kidney and tumor growth.
体内研究：
(-)-Fucose (100mg，腹腔注射，单或双剂量) 阻断 CL-11 相关补体 C3d 在缺氧肾小管细胞上的沉积，揭示了对 C57BL/6 小鼠中具有 CL11 依赖性的 I/R 损伤的保护作用。(-)-Fucose (1-5 g/kg/d，腹腔注射，11 天) 在携带 SET 肿瘤的 NMRI 小鼠体内可以抑制肿瘤生长和有丝分裂活性，促进肿瘤转移。Animal Model:CL11+/+ and CL11-/- C57BL/6 mice
Dosage:100 mg
Administration:intraperitoneal injection, 1 h before ischemia induction or 1 h prior and a secong dose immediately following reperfusion.
Result:Decreased C3d deposition in CL+/+ C57BL/6 mice.
Animal Model:SET bearing NMRI mice
Dosage:1-5 g/kg
Administration:intraperitoneal injection, once everyday for 11 days.
Result:Inhibited tumor growth, induced tumor metastasis.
体外研究：
(-)-Fucose (8-80 mM) 抑制 CL-11 与固定配体的结合并消除补体激活的触发因素，IC50 为 12.2 mM。
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