产品
编 号：F289343
分子式：C17H20O6
分子量：320.34
分子式：C17H20O6
分子量：320.34
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
440
In-stock
500mg
880
In-stock
结构图
CAS No: 24280-93-1
产品详情
生物活性：
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
体内研究：
Mycophenolic acid 通过调节肿瘤微环境发挥抗肿瘤作用，在 BALB/c 裸鼠体内显著抑制 U87 肿瘤生长。Animal Model:Athymic 8-week-old, 20 g BALB/c?nu/nu?mice bearing Mycophenolic acid-resistant human U87 tumor model
Dosage:120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid)
Administration:Oral gavage; b.i.d.
Result:MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (～70% after day 14 after tumor implantation) in MMF-treated versus control mice.Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).
体外研究：
Mycophenolic acid 对多种 RNA 病毒具有抗病毒作用，包括流感、登革热病毒、寨卡病毒、轮状病毒、CCHFV 和汉坦病毒。IMPDH 是病毒中的限速酶鸟苷核苷酸的从头合成。 Mycophenolic acid (0.01-1 μM；72 小时) 对内皮细胞和成纤维细胞表现出优先的抗增殖活性.内皮细胞是对 Mycophenolic acid 处理最敏感的细胞，其抗有丝分裂作用的 IC50 Mycophenolic acid 相关抗体:Cell Proliferation AssayCell Line:Primary isolated human dermal microvascular endothelial cells (HDMVEC)?, fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells,A549 non-small cell lung cancer cells
Concentration:0.01, 0.1, 1 μM
Incubation Time:72 hours
Result:Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity.?
Western Blot AnalysisCell Line:HDMVEC
Concentration:0, 0.05, 0.1, 0.5, 1, and 2 μM
Incubation Time:18 hours
Result:Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.?
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM.?Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
体内研究：
Mycophenolic acid 通过调节肿瘤微环境发挥抗肿瘤作用，在 BALB/c 裸鼠体内显著抑制 U87 肿瘤生长。Animal Model:Athymic 8-week-old, 20 g BALB/c?nu/nu?mice bearing Mycophenolic acid-resistant human U87 tumor model
Dosage:120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid)
Administration:Oral gavage; b.i.d.
Result:MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (～70% after day 14 after tumor implantation) in MMF-treated versus control mice.Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).
体外研究：
Mycophenolic acid 对多种 RNA 病毒具有抗病毒作用，包括流感、登革热病毒、寨卡病毒、轮状病毒、CCHFV 和汉坦病毒。IMPDH 是病毒中的限速酶鸟苷核苷酸的从头合成。 Mycophenolic acid (0.01-1 μM；72 小时) 对内皮细胞和成纤维细胞表现出优先的抗增殖活性.内皮细胞是对 Mycophenolic acid 处理最敏感的细胞，其抗有丝分裂作用的 IC50 Mycophenolic acid 相关抗体:Cell Proliferation AssayCell Line:Primary isolated human dermal microvascular endothelial cells (HDMVEC)?, fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells,A549 non-small cell lung cancer cells
Concentration:0.01, 0.1, 1 μM
Incubation Time:72 hours
Result:Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity.?
Western Blot AnalysisCell Line:HDMVEC
Concentration:0, 0.05, 0.1, 0.5, 1, and 2 μM
Incubation Time:18 hours
Result:Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.?
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备