产品
编 号：F289126
分子式：C17H20N2O2S
分子量：316.42
分子式：C17H20N2O2S
分子量：316.42
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 24237-54-5
产品详情
生物活性：
Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. .
体内研究：
Tinoridine (100 mg/kg; p.o.; single dose) inhibits CCl4 hepatotoxicity in rats, with a strong control of the CCl4-induced enzyme activities.Tinoridine (100 mg/kg; i.p.; single dose) protects the stability of rat liver and kidney lysosomes in vivo.Animal Model:Male Wistar rats (180-220 g)
Dosage:100 mg/kg
Administration:Oral gavage; single dose; 1 hour before CCl4 (i.p.; 0.25 mL/kg) treatment
Result:Inhibited the CCl4-induced enzyme activities increase of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and also rescued the liver microsomal cytochrome P-450 and glucose-6-phosphatase activities.
体外研究：
Tinoridine (10-100 μM) exerts effect on stability of rat liver and kidney lysosomes, and liver parenchymal cells.Tinoridine (1, 10, and 100 μM; 30 min) inhibits spontaneous release of acid phosphatase from liver lymomoses in vitro.
Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. .
体内研究：
Tinoridine (100 mg/kg; p.o.; single dose) inhibits CCl4 hepatotoxicity in rats, with a strong control of the CCl4-induced enzyme activities.Tinoridine (100 mg/kg; i.p.; single dose) protects the stability of rat liver and kidney lysosomes in vivo.Animal Model:Male Wistar rats (180-220 g)
Dosage:100 mg/kg
Administration:Oral gavage; single dose; 1 hour before CCl4 (i.p.; 0.25 mL/kg) treatment
Result:Inhibited the CCl4-induced enzyme activities increase of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and also rescued the liver microsomal cytochrome P-450 and glucose-6-phosphatase activities.
体外研究：
Tinoridine (10-100 μM) exerts effect on stability of rat liver and kidney lysosomes, and liver parenchymal cells.Tinoridine (1, 10, and 100 μM; 30 min) inhibits spontaneous release of acid phosphatase from liver lymomoses in vitro.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备