产品
编 号：F033004
分子式：C24H24F3N5O3
分子量：487.47
分子式：C24H24F3N5O3
分子量：487.47
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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结构图
CAS No: 1092453-15-0
产品详情
生物活性：
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
体内研究：
AZD-8529 (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. AZD-8529 (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats.Animal Model:Sprague-Dawley rats
Dosage:10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection; 2 hours before nicotine injections
Result:Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats.
体外研究：
AZD-8529 potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM.AZD-8529 does not elicit antagonist responses on mGluRs at 25 μM.
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
体内研究：
AZD-8529 (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. AZD-8529 (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats.Animal Model:Sprague-Dawley rats
Dosage:10 mg/kg, 30 mg/kg
Administration:Intraperitoneal injection; 2 hours before nicotine injections
Result:Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats.
体外研究：
AZD-8529 potentiates the effects of glutamate at mGluR2 with an EC50 of 195 nM.AZD-8529 does not elicit antagonist responses on mGluRs at 25 μM.
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