产品
编 号：F288152
分子式：C16H27BrN2O
分子量：343.3
分子式：C16H27BrN2O
分子量：343.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 24003-58-5
产品详情
生物活性：
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
体内研究：
QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.Animal Model:Male Sprague-Dawley rats (250-290 g)
Dosage:1.6 mg/kg
Administration:Intracutaneous injection
Result:Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
体外研究：
QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average QX-314 bromide 相关抗体:
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker.
体内研究：
QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.Animal Model:Male Sprague-Dawley rats (250-290 g)
Dosage:1.6 mg/kg
Administration:Intracutaneous injection
Result:Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
体外研究：
QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca2+ currents are on average QX-314 bromide 相关抗体:
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