产品
编 号:F288124
分子式:C19H17NOS
分子量:307.41
产品类型
结构图
CAS No: 2398-96-1
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产品详情
生物活性:
Tolnaftate (NP-27) is a synthetic thiocarbamate used as an anti-fungal agent. .
体外研究:
Tolnaftate (NP-27) blocked sterol biosynthesis in fungal cells and cell extracts, with accumulation of squalene. This point of action was confirmed by the direct inhibition of microsomal squalene epoxidase from Candida albicans. Tolnaftate (NP-27) inhibited sterol biosynthesis, At 100 microM, tolnaftate caused up to a 30% release of intracellular [14C]aminoisobutyric acid.