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编 号：F287704
分子式：C10H18N4O6
分子量：290.27
分子式：C10H18N4O6
分子量：290.27
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CAS No: 2387-71-5
产品详情
生物活性：
Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain.
体内研究：
Argininosuccinic acid (2 μM, 2 μL; 头部注射; 单剂量) 能显著诱导 30 日龄大鼠的氧化应激。Animal Model:30-day-old rats with two small holes drilled in the skull
Dosage:2 μL of a 1.0 M concentration (2 μmol in 2 μL)
Administration:Injection; euthanized 2 h after treatment
Result:Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation).Significantly decreased GSH concentrations.
体外研究：
Argininosuccinic acid (250-1000 μM; 1 h) 显著增加丙二醛水平，减少巯基和羰基的形成 (蛋白质氧化) 在大脑皮层。Argininosuccinic acid (250-1000 μM; 1 h) 降低 30 日龄大鼠大脑皮层还原性谷胱甘肽 (GSH) 浓度。Argininosuccinic acid (500 μM; 1 h) 增加了30 日龄大鼠大脑皮层的二氯荧光黄含量。
Argininosuccinic acid participates in the fourth step of the urea cycle, with being cleaved to arginine and fumaric acid by argininosuccinic acid lyase (ASL). Argininosuccinic acid reduces reduced glutathione (GSH) level, and increases the production of reactive oxygen species in cerebral cortex and striatum. Argininosuccinic acid causes lipid peroxidation and protein oxidation, and induces oxidative stress in the developing rat brain.
体内研究：
Argininosuccinic acid (2 μM, 2 μL; 头部注射; 单剂量) 能显著诱导 30 日龄大鼠的氧化应激。Animal Model:30-day-old rats with two small holes drilled in the skull
Dosage:2 μL of a 1.0 M concentration (2 μmol in 2 μL)
Administration:Injection; euthanized 2 h after treatment
Result:Significantly induced lipid oxidation (MDA levels) and protein oxidation (carbonyl formation), increased ROS and RNS generation (DCFH oxidation).Significantly decreased GSH concentrations.
体外研究：
Argininosuccinic acid (250-1000 μM; 1 h) 显著增加丙二醛水平，减少巯基和羰基的形成 (蛋白质氧化) 在大脑皮层。Argininosuccinic acid (250-1000 μM; 1 h) 降低 30 日龄大鼠大脑皮层还原性谷胱甘肽 (GSH) 浓度。Argininosuccinic acid (500 μM; 1 h) 增加了30 日龄大鼠大脑皮层的二氯荧光黄含量。
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