产品
编 号:F287515
分子式:C13H19Br2ClN2O
分子量:414.56
产品类型
结构图
CAS No: 23828-92-4
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产品详情
生物活性:
Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.
体内研究:
Ambroxol hydrochloride (NA-872 hydrochloride;在饮用水中连续 12 天浓度为 1、3、4、5 mM) 导致野生型小鼠大脑葡萄糖脑苷脂酶活性增加,转基因小鼠在小鼠葡萄糖脑苷脂酶 1 基因中表达杂合 L444P 突变,和过表达人 α-突触核蛋白的转基因小鼠。