产品
编 号：F287444
分子式：C15H26O
分子量：222.37
分子式：C15H26O
分子量：222.37
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CAS No: 23811-08-7
产品详情
生物活性：
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer.
体外研究：
(-)-Hinesol (0-25 μg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner.(-)-Hinesol (0, 2, 8 μg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1.(-)-Hinesol (0, 2, 8 μg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change forthe total protein levels of IκBα and p65 in A549 cells.
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer.
体外研究：
(-)-Hinesol (0-25 μg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner.(-)-Hinesol (0, 2, 8 μg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1.(-)-Hinesol (0, 2, 8 μg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change forthe total protein levels of IκBα and p65 in A549 cells.
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