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编 号:F287248
分子式:C31H33ClN4O4
分子量:561.07
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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生物活性:
K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.

体外研究:
K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells.K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells.
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