产品
编 号:F287248
分子式:C31H33ClN4O4
分子量:561.07
产品类型
结构图
CAS No: 2376328-55-9
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产品详情
生物活性:
K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.
体外研究:
K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells.K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells.