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编 号:F286835
分子式:C25H31FN8
分子量:462.57
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生物活性:
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 nM and 2.2 nM, respectively. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. CDK4/6-IN-3 can be used for the treatment of glioblastoma.

体外研究:
CDK4/6-IN-3 (Compound 24) inhibits MCF7 and BT549 cell lines proliferation with EC50s of 30 nM and 2.1 μM, respectively.
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