产品
编 号：F286337
分子式：C27H30ClNO10
分子量：563.98
分子式：C27H30ClNO10
分子量：563.98
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
257
In-stock
10mg
412
In-stock
50mg
1280
In-stock
100mg
2000
In-stock
200mg
2800
In-stock
500mg
5600
In-stock
结构图
CAS No: 23541-50-6
产品详情
生物活性：
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
体内研究：
Daunorubicin hydrochloride (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.Animal Model:Male Sprague-Dawley rats
Dosage:3 mg/kg
Administration:Intravenous injection, three times at 48 h intervals.
Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.
体外研究：
Daunorubicin hydrochloride (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.Daunorubicin hydrochloride (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin hydrochloride (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin hydrochloride (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).
Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor.
体内研究：
Daunorubicin hydrochloride (intravenous injection, 3 mg/kg, three times at 48 h intervals.) produces cardiotoxicity and nephrotoxicity in rats.Daunorubicin hydrochloride (intraperitoneal injection, 10 mg/kg) induces sister chromatid exchanges in mice.Animal Model:Male Sprague-Dawley rats
Dosage:3 mg/kg
Administration:Intravenous injection, three times at 48 h intervals.
Result:Caused a significant increase in MDA (malondialdehyde) level in renal tissue, accompanied by a significant reduction in total GPx activity.Increased urinary protein excretion, serum creatinine, and BUN level.
体外研究：
Daunorubicin hydrochloride (0-256 μg/mL, 30 min) inhibits DNA and RNA synthesis in sensitive and resistant Ehrlich ascites tumor cells.Daunorubicin hydrochloride (7 nM-1.9 μM, 72 h) shows chemosensitivity in Molt-4 cells and L3.6 cells.Daunorubicin hydrochloride (0.4 μM, 48 h) induces apoptotic and necrosis in L3.6 cells.Daunorubicin hydrochloride (0.4 μM, 120 min) induces ROS generation in L3.6 cells.Daunorubicin hydrochloride (2 μM, 24 h) induces autophagy in K562 cells (myeloid cell line).
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