产品
编 号：F285067
分子式：C26H39NO10
分子量：525.59
分子式：C26H39NO10
分子量：525.59
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
500mg
询价
询价
结构图
CAS No: 23142-01-0
产品详情
生物活性：
Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.
体内研究：
Pentoxyverine (Carbetapentane；1-32mg/kg；皮下给药) citrate 在小鼠的爪子注射辣椒素 (HY-10448) 进行刺激下，可以剂量依赖性地增强辣椒素对机械刺激的敏化作用。Pentoxyverine (16?mg/kg；皮下给药) citrate 对辣椒素引起的继发性机械异常性疼痛有很强的增强作用。Pentoxyverine (50?mg/kg；口服) citrate 可以用作阳性对照，对任一性别的小鼠 (22-25?g) 给药7天后，使氨水诱导的咳嗽潜伏期百分比增加121.72％，抑制咳嗽频率45.45％。 Animal Model:Female wild-type weighing 25 to 30?g
Dosage:0.5, 1, 2, 4, 8, 16, 32 mg/kg
Administration:SC; 30?min before the intraplantar (i.pl.) administration of capsaicin (0.125?μg)
Result:Dose-dependently potentiated the sensitizing effect of capsaicin to the mechanical stimulus when the mice were stimulated in the paw injected with capsaicin.
Pentoxyverine (Carbetapentane) citrate is an orally active sigma-1 receptor agonist, with Kis of 41 nM, 894 nM and 75 nM for σ1, σ2 and guinea-pig brain membrane σ1, respectively. Pentoxyverine citrate is a muscarinic antagonist. Pentoxyverine citrate is a potent antitussive, anticonvulsant, and spasmolytic agent. Pentoxyverine citrate can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance.
体内研究：
Pentoxyverine (Carbetapentane；1-32mg/kg；皮下给药) citrate 在小鼠的爪子注射辣椒素 (HY-10448) 进行刺激下，可以剂量依赖性地增强辣椒素对机械刺激的敏化作用。Pentoxyverine (16?mg/kg；皮下给药) citrate 对辣椒素引起的继发性机械异常性疼痛有很强的增强作用。Pentoxyverine (50?mg/kg；口服) citrate 可以用作阳性对照，对任一性别的小鼠 (22-25?g) 给药7天后，使氨水诱导的咳嗽潜伏期百分比增加121.72％，抑制咳嗽频率45.45％。 Animal Model:Female wild-type weighing 25 to 30?g
Dosage:0.5, 1, 2, 4, 8, 16, 32 mg/kg
Administration:SC; 30?min before the intraplantar (i.pl.) administration of capsaicin (0.125?μg)
Result:Dose-dependently potentiated the sensitizing effect of capsaicin to the mechanical stimulus when the mice were stimulated in the paw injected with capsaicin.
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