产品
编 号：F285047
分子式：C21H19F3N4O4
分子量：448.4
分子式：C21H19F3N4O4
分子量：448.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
询价
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50mg
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结构图
CAS No: 2313526-86-0
产品详情
生物活性：
VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.
体内研究：
VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice.Animal Model:C57Bl/6J male mice (8 weeks old)
Dosage:1, 3, and 10 mg/kg
Administration:I.p. injections; 60 minutes prior to testing
Result:Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.
体外研究：
VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes.
VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.
体内研究：
VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice.Animal Model:C57Bl/6J male mice (8 weeks old)
Dosage:1, 3, and 10 mg/kg
Administration:I.p. injections; 60 minutes prior to testing
Result:Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.
体外研究：
VU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes.
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