产品
编 号：F284902
分子式：C18H17NO
分子量：263.33
分子式：C18H17NO
分子量：263.33
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 23095-44-5
产品详情
生物活性：
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.
体内研究：
Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid. In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos.Animal Model:Male ICR mice (25-35 g) treated with carrageenan
Dosage:10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:Orally gavage; once
Result:Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.
体外研究：
Girinimbine (1-400 μM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 μM, 56 μM, and 40 μM respectively. Girinimbine (10-100 μM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells.Girinimbine (56 μM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells.HepG2 cells.Girinimbine (56 μM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 μg/mL.
Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities.
体内研究：
Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid. In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos.Animal Model:Male ICR mice (25-35 g) treated with carrageenan
Dosage:10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration:Orally gavage; once
Result:Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.
体外研究：
Girinimbine (1-400 μM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 μM, 56 μM, and 40 μM respectively. Girinimbine (10-100 μM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells.Girinimbine (56 μM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells.HepG2 cells.Girinimbine (56 μM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest.Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 μg/mL.
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