产品
编 号：F284824
分子式：C12H17ClN2S
分子量：256.79
分子式：C12H17ClN2S
分子量：256.79
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
100mg
询价
询价
500mg
询价
询价
结构图
CAS No: 23076-35-9
产品详情
生物活性：
Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.
体内研究：
Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment.Animal Model:Male Sprague-Dawley rats (160-180 g)
Dosage:5.2 mg/kg
Administration:Intraperitoneal injection; for 10 minutes, 20 minutes, 40 minutesor 60 minutes
Result:Increased in AMPK activity in the cerebral cortex, hippocampus, thalamus and cerebellum. Phosphorylated LKB1 and AMPKα protein levels were decreased.
Xylazine hydrochloride (BAY 1470 hydrochloride) is a strong α2-adrenergic agonist whose effects are mediated via stimulation of central α2-receptors. Xylazine hydrochloride is used as a sedative, analgesic and muscle relaxant in veterinary medicine.
体内研究：
Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment.Animal Model:Male Sprague-Dawley rats (160-180 g)
Dosage:5.2 mg/kg
Administration:Intraperitoneal injection; for 10 minutes, 20 minutes, 40 minutesor 60 minutes
Result:Increased in AMPK activity in the cerebral cortex, hippocampus, thalamus and cerebellum. Phosphorylated LKB1 and AMPKα protein levels were decreased.
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